RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death. Its downregulation in Parkinson’s and Huntington’s disease models ameliorates the pathological phenotypes. In the context of Alzheimer’s disease (AD), the coding gene for RTP801,
DDIT4
, is responsive to Aβ and modulates its cy...
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Full title
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_dd2fb29473404df5adcecc84c09efbe1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dd2fb29473404df5adcecc84c09efbe1
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-03899-y
