Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma
Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma
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Publisher
England: BMJ Publishing Group Ltd
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Language
English
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Publisher
England: BMJ Publishing Group Ltd
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Contents
BackgroundCell therapies for solid tumors are thwarted by the hostile tumor microenvironment (TME) and by heterogeneous expression of tumor target antigens. We address both limitations with a novel class of chimeric antigen receptors based on plant lectins, which recognize the aberrant sugar residues that are a ‘hallmark’ of both malignant and asso...
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Full title
Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma
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TN_cdi_doaj_primary_oai_doaj_org_article_dd3ceb49b32e483f92d49b7f902abc2c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dd3ceb49b32e483f92d49b7f902abc2c
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2022-005891
