PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 s...
PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Regulatory T (Treg) cells are central to limit immune responses to allergens. Here we show that PD-L2 deficiency prevents the induction of tolerance to ovalbumin and control of airway hyperreactivity, in particular by limiting pTreg numbers and function. In vitro, PD-1/PD-L2 interactions increase iTreg numbers and stability. In mice lacking PD-L2 w...
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Full title
PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability
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TN_cdi_doaj_primary_oai_doaj_org_article_dd4e965ac85f475c9f66e78325872bc5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dd4e965ac85f475c9f66e78325872bc5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32899-5
