Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human induced pluripotent stem cell-derived motor neurons (iPSMNs) offer a solution; however, studies have typically...
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Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology
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TN_cdi_doaj_primary_oai_doaj_org_article_dd8f26a91a1646ca8fb84eb2c02762b3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dd8f26a91a1646ca8fb84eb2c02762b3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37630-6
