Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
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Author / Creator
Zhao, Li , Wang, Shumei , Xu, Meng , He, Yang , Zhang, Xiaowei , Xiong, Ying , Sun, Hong , Ding, Haibo , Geng, Wenqing , Shang, Hong and Liang, Guoxin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The HIV-1 accessory proteins Vif, Vpu, and Nef can promote infection by overcoming the inhibitory effects of the host cell restriction factors APOBEC3G, Tetherin, and SERINC5, respectively. However, how the HIV-1 accessory protein Vpr enhances infection in macrophages but not in CD4
+
T cells remains elusive. Here, we report that Vpr countera...
Alternative Titles
Full title
Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ddd5c835dbf9457c830d0075ef2284e0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ddd5c835dbf9457c830d0075ef2284e0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24087-8
