RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthrit...
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
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Author / Creator
Venken, Koen , Jacques, Peggy , Mortier, Céline , Labadia, Mark E. , Decruy, Tine , Coudenys, Julie , Hoyt, Kathleen , Wayne, Anita L. , Hughes, Robert , Turner, Michael , Van Gassen, Sofie , Martens, Liesbet , Smith, Dustin , Harcken, Christian , Wahle, Joseph , Wang, Chao-Ting , Verheugen, Eveline , Schryvers, Nadia , Varkas, Gaëlle , Cypers, Heleen , Wittoek, Ruth , Piette, Yves , Gyselbrecht, Lieve , Van Calenbergh, Serge , Van den Bosch, Filip , Saeys, Yvan , Nabozny, Gerald and Elewaut, Dirk
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including invariant natural killer T (iNKT) and γδ-T cells, but their contribution to SpA is still unclear. Here...
Alternative Titles
Full title
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
Authors, Artists and Contributors
Author / Creator
Jacques, Peggy
Mortier, Céline
Labadia, Mark E.
Decruy, Tine
Coudenys, Julie
Hoyt, Kathleen
Wayne, Anita L.
Hughes, Robert
Turner, Michael
Van Gassen, Sofie
Martens, Liesbet
Smith, Dustin
Harcken, Christian
Wahle, Joseph
Wang, Chao-Ting
Verheugen, Eveline
Schryvers, Nadia
Varkas, Gaëlle
Cypers, Heleen
Wittoek, Ruth
Piette, Yves
Gyselbrecht, Lieve
Van Calenbergh, Serge
Van den Bosch, Filip
Saeys, Yvan
Nabozny, Gerald
Elewaut, Dirk
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ddd72678135941fdb84362715749b1f1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ddd72678135941fdb84362715749b1f1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07911-6
