Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
About this item
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Author / Creator
Chen, Xiaohua , Zhang, Taotao , Su, Wei , Dou, Zhihui , Zhao, Dapeng , Jin, Xiaodong , Lei, Huiwen , Wang, Jing , Xie, Xiaodong , Cheng, Bo , Li, Qiang , Zhang, Hong and Di, Cuixia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
TP53
, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed “gain-of-function”. Emerging evidence suggests that mutp53 is highly associated with advanced malignancies and poor pr...
Alternative Titles
Full title
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_de3ebfc8fd634078865f3b7040816cf0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_de3ebfc8fd634078865f3b7040816cf0
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-05408-1
