Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular...
Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma
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Author / Creator
He, Meng , Liu, Yongxiang , Chen, Song , Deng, Haijing , Feng, Cheng , Qiao, Shuang , Chen, Qifeng , Hu, Yue , Chen, Huiming , Wang, Xun , Jiang, Xiongying , Xia, Xiaojun , Zhao, Ming and Lyu, Ning
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
The response to programmed death-1 (PD-1) blockade varies in hepatocellular carcinoma (HCC). We utilize a panel of 16 serum factors to show that a circulating level of serum amyloid A (SAA) > 20.0 mg/L has the highest accuracy in predicting anti-PD-1 resistance in HCC. Further experiments show a correlation between peritumoral SAA expression and ci...
Alternative Titles
Full title
Serum amyloid A promotes glycolysis of neutrophils during PD-1 blockade resistance in hepatocellular carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_de91ee4513664ee88d2c7da1981cba94
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_de91ee4513664ee88d2c7da1981cba94
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-46118-w
