Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
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Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Altered mitochondrial dynamics can broadly impact tumor cell physiology. Using genetic and pharmacological profiling of cancer cell lines and human tumors, we here establish that perturbations to the mitochondrial dynamics network also result in specific therapeutic vulnerabilities. In particular, through distinct mechanisms, tumors with increased...
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Full title
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
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TN_cdi_doaj_primary_oai_doaj_org_article_de9748c806cf4ead9e12f2fd548f0dad
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_de9748c806cf4ead9e12f2fd548f0dad
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04033-x
