TR1801‐ADC: a highly potent cMet antibody–drug conjugate with high activity in patient‐derived xenog...
TR1801‐ADC: a highly potent cMet antibody–drug conjugate with high activity in patient‐derived xenograft models of solid tumors
About this item
Full title
Author / Creator
Gymnopoulos, Marco , Betancourt, Oscar , Blot, Vincent , Fujita, Ryo , Galvan, Diana , Lieuw, Vincent , Nguyen, Sophie , Snedden, Jeanette , Stewart, Christine , Villicana, Jose , Wojciak, Jon , Wong, Eley , Pardo, Raul , Patel, Neki , D’Hooge, Francois , Vijayakrishnan, Balakumar , Barry, Conor , Hartley, John A. , Howard, Philip W. , Newman, Roland and Coronella, Julia
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
United States: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
cMet is a well‐characterized oncogene that is the target of many drugs including small molecule and biologic pathway inhibitors, and, more recently, antibody–drug conjugates (ADCs). However, the clinical benefit from cMet‐targeted therapy has been limited. We developed a novel cMet‐targeted ‘third‐generation’ ADC, TR1801‐ADC, that was optimized at...
Alternative Titles
Full title
TR1801‐ADC: a highly potent cMet antibody–drug conjugate with high activity in patient‐derived xenograft models of solid tumors
Authors, Artists and Contributors
Author / Creator
Betancourt, Oscar
Blot, Vincent
Fujita, Ryo
Galvan, Diana
Lieuw, Vincent
Nguyen, Sophie
Snedden, Jeanette
Stewart, Christine
Villicana, Jose
Wojciak, Jon
Wong, Eley
Pardo, Raul
Patel, Neki
D’Hooge, Francois
Vijayakrishnan, Balakumar
Barry, Conor
Hartley, John A.
Howard, Philip W.
Newman, Roland
Coronella, Julia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_deb621ff4dba44b3a242c7c4570c902e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_deb621ff4dba44b3a242c7c4570c902e
Other Identifiers
ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1002/1878-0261.12600
