HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance vi...
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma
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Author / Creator
Xu, Qiuran , Tu, Jianfeng , Dou, Changwei , Zhang, Jun , Yang, Liu , Liu, Xin , Lei, Kefeng , Liu, Zhikui , Wang, Yufeng , Li, Lijie , Bao, Hangxing , Wang, Jiahui and Tu, Kangsheng
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Heat shock protein 90 (HSP90) functions as a well-known onco-protein to regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a critical regulator of the metabolism, growth and metastasis of cancer cells, has been confirmed to be overexpressed in various human cancer including hepatocellular carcinoma (HCC). However,...
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Full title
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_df232d7e819f4973b69de5f6044f777a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_df232d7e819f4973b69de5f6044f777a
Other Identifiers
ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-017-0748-y
