Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress
Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress
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Author / Creator
You, Zhiyuan , Jiang, Wen-Xue , Qin, Ling-Yun , Gong, Zhou , Wan, Wei , Li, Jin , Wang, Yusha , Zhang, Hongtao , Peng, Chao , Zhou, Tianhua , Tang, Chun and Liu, Wei
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Autophagy receptor p62/SQSTM1 promotes the assembly and removal of ubiquitylated proteins by forming p62 bodies and mediating their encapsulation in autophagosomes. Here we show that under nutrient-deficient conditions, cellular p62 specifically undergoes acetylation, which is required for the formation and subsequent autophagic clearance of p62 bo...
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Full title
Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_df3739c6d5be4f2fb8d8248924f5b8fd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_df3739c6d5be4f2fb8d8248924f5b8fd
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13718-w
