Effective control of large deletions after double-strand breaks by homology-directed repair and dsOD...
Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion
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Author / Creator
Wen, Wei , Quan, Zi-Jun , Li, Si-Ang , Yang, Zhi-Xue , Fu, Ya-Wen , Zhang, Feng , Li, Guo-Hua , Zhao, Mei , Yin, Meng-Di , Xu, Jing , Zhang, Jian-Ping , Cheng, Tao and Zhang, Xiao-Bing
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
After repairing double-strand breaks (DSBs) caused by CRISPR-Cas9 cleavage, genomic damage, such as large deletions, may have pathogenic consequences.
We show that large deletions are ubiquitous but are dependent on editing sites and cell types. Human primary T cells display more significant deletions than hematopoietic stem and progenitor cells...
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Full title
Effective control of large deletions after double-strand breaks by homology-directed repair and dsODN insertion
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TN_cdi_doaj_primary_oai_doaj_org_article_df51a80f1e864427bde4af68b40acd79
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_df51a80f1e864427bde4af68b40acd79
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-021-02462-4
