Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal...
Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Lineage plasticity has been proposed as a major source of intratumoral heterogeneity and therapeutic resistance. Here, by employing an inducible genetic engineered mouse model, we illustrate that lineage plasticity enables advanced Pancreatic Ductal Adenocarcinoma (PDAC) tumors to develop spontaneous relapse following elimination of the central onc...
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Full title
Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas
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TN_cdi_doaj_primary_oai_doaj_org_article_df63191ad5df4c8da8cf9519ea7988c1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_df63191ad5df4c8da8cf9519ea7988c1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37147-y
