Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic...
Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia
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Author / Creator
Sayyab, Shumaila , Lundmark, Anders , Larsson, Malin , Ringnér, Markus , Nystedt, Sara , Marincevic-Zuniga, Yanara , Tamm, Katja Pokrovskaja , Abrahamsson, Jonas , Fogelstrand, Linda , Heyman, Mats , Norén-Nyström, Ulrika , Lönnerholm, Gudmar , Harila-Saari, Arja , Berglund, Eva C. , Nordlund, Jessica and Syvänen, Ann-Christine
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome sequencing of samples collected at diagnosis, relapse(s) and remission from 29 Nordic patients. Somatic point mutations and large-scale structural variants were called using individua...
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Full title
Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_df7f00d635d847359cec38029b48a552
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_df7f00d635d847359cec38029b48a552
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-95109-0
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