Selectively targeting myeloid-derived suppressor cells through TRAIL receptor 2 to enhance the effic...
Selectively targeting myeloid-derived suppressor cells through TRAIL receptor 2 to enhance the efficacy of CAR T cell therapy for treatment of breast cancer
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England: BMJ Publishing Group Ltd
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Language
English
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Publisher
England: BMJ Publishing Group Ltd
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BackgroundSuccessful targeting of solid tumors such as breast cancer (BC) using chimeric antigen receptor (CAR) T cells has proven challenging, largely attributed to the immunosuppressive tumor microenvironment (TME). Myeloid-derived suppressor cells (MDSCs) inhibit CAR T cell function and persistence within the breast TME. To overcome this challen...
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Full title
Selectively targeting myeloid-derived suppressor cells through TRAIL receptor 2 to enhance the efficacy of CAR T cell therapy for treatment of breast cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_dfbeb4bf866d41e59ad5cc0c77aedfd1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dfbeb4bf866d41e59ad5cc0c77aedfd1
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-003237
