Caveolin‐3 loss linked with the P104L LGMD‐1C mutation modulates skeletal muscle mTORC1 signalling a...
Caveolin‐3 loss linked with the P104L LGMD‐1C mutation modulates skeletal muscle mTORC1 signalling and cholesterol homeostasis
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Heidelberg: John Wiley & Sons, Inc
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English
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Heidelberg: John Wiley & Sons, Inc
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BackgroundCaveolins are the principal structural components of plasma membrane caveolae. Dominant pathogenic mutations in the muscle-specific caveolin-3 (Cav3) gene isoform, such as the limb girdle muscular dystrophy type 1C (LGMD-1C) P104L mutation, result in dramatic loss of the Cav3 protein and pathophysiological muscle weakness/wasting. We hypo...
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Caveolin‐3 loss linked with the P104L LGMD‐1C mutation modulates skeletal muscle mTORC1 signalling and cholesterol homeostasis
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TN_cdi_doaj_primary_oai_doaj_org_article_e035219594ad4502848bc7b29c515f6a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e035219594ad4502848bc7b29c515f6a
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2190-5991
E-ISSN
2190-6009
DOI
10.1002/jcsm.13317
