A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to p...
A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to protein insolubility
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Vertebrate CMP-sialic acid synthetase (CSS), which catalyzes the synthesis of CMP-sialic acid (CMP-Sia), consists of a 28 kDa-N-domain and a 20 kDa-C-domain. The N-domain is known to be a catalytic domain; however, the significance of the C-domain still remains unknown. To elucidate the function of the C-domain at the organism level, we screened th...
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A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to protein insolubility
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TN_cdi_doaj_primary_oai_doaj_org_article_e0661301453f45079fe8ecf59607b6f8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e0661301453f45079fe8ecf59607b6f8
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-01715-3
