A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
About this item
Full title
Author / Creator
Saul, Dominik , Kosinsky, Robyn Laura , Atkinson, Elizabeth J. , Doolittle, Madison L. , Zhang, Xu , LeBrasseur, Nathan K. , Pignolo, Robert J. , Robbins, Paul D. , Niedernhofer, Laura J. , Ikeno, Yuji , Jurk, Diana , Passos, João F. , Hickson, LaTonya J. , Xue, Ailing , Monroe, David G. , Tchkonia, Tamara , Kirkland, James L. , Farr, Joshua N. and Khosla, Sundeep
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell identification remains challenging. Here, we generate a gene set (SenMayo) and validate its enrichment in bone biopsies from two aged human cohorts. We further demonstrate reductions in SenMayo in bon...
Alternative Titles
Full title
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Authors, Artists and Contributors
Author / Creator
Kosinsky, Robyn Laura
Atkinson, Elizabeth J.
Doolittle, Madison L.
Zhang, Xu
LeBrasseur, Nathan K.
Pignolo, Robert J.
Robbins, Paul D.
Niedernhofer, Laura J.
Ikeno, Yuji
Jurk, Diana
Passos, João F.
Hickson, LaTonya J.
Xue, Ailing
Monroe, David G.
Tchkonia, Tamara
Kirkland, James L.
Farr, Joshua N.
Khosla, Sundeep
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e07e402c5be742719a9abae3ab241ab2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e07e402c5be742719a9abae3ab241ab2
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32552-1
