Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol. However, the determinants of TDP-43 localization and the cellular insults that promote redistribution are incompletely understood. Here...
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Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
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TN_cdi_doaj_primary_oai_doaj_org_article_e0bc0cffa6c242cf85832575acd6acd8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e0bc0cffa6c242cf85832575acd6acd8
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-25008-4
