Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
About this item
Full title
Author / Creator
Aubert, Léo , Nandagopal, Neethi , Steinhart, Zachary , Lavoie, Geneviève , Nourreddine, Sami , Berman, Jacob , Saba-El-Leil, Marc K. , Papadopoli, David , Lin, Sichun , Hart, Traver , Macleod, Graham , Topisirovic, Ivan , Gaboury, Louis , Fahrni, Christoph J. , Schramek, Daniel , Meloche, Sylvain , Angers, Stephane and Roux, Philippe P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic KRAS has been extremely challenging to target therapeutically. To identify potential vulnerabilities in KRAS-mutated CRC, we characterize the impact of oncogenic KRAS on the cell surface of intestinal epithelial cells. Here we show that oncogenic KRAS alters the...
Alternative Titles
Full title
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
Authors, Artists and Contributors
Author / Creator
Nandagopal, Neethi
Steinhart, Zachary
Lavoie, Geneviève
Nourreddine, Sami
Berman, Jacob
Saba-El-Leil, Marc K.
Papadopoli, David
Lin, Sichun
Hart, Traver
Macleod, Graham
Topisirovic, Ivan
Gaboury, Louis
Fahrni, Christoph J.
Schramek, Daniel
Meloche, Sylvain
Angers, Stephane
Roux, Philippe P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e0ea73c88dab4e7c804e408236956ef7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e0ea73c88dab4e7c804e408236956ef7
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17549-y
