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Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e0ea73c88dab4e7c804e408236956ef7

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

About this item

Full title

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2020-07, Vol.11 (1), p.3701-15, Article 3701

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic KRAS has been extremely challenging to target therapeutically. To identify potential vulnerabilities in KRAS-mutated CRC, we characterize the impact of oncogenic KRAS on the cell surface of intestinal epithelial cells. Here we show that oncogenic KRAS alters the...

Alternative Titles

Full title

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_e0ea73c88dab4e7c804e408236956ef7

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e0ea73c88dab4e7c804e408236956ef7

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-020-17549-y

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