Thrombopoiesis is spatially regulated by the bone marrow vasculature
Thrombopoiesis is spatially regulated by the bone marrow vasculature
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Author / Creator
Stegner, David , vanEeuwijk, Judith M. M. , Angay, Oğuzhan , Gorelashvili, Maximilian G. , Semeniak, Daniela , Pinnecker, Jürgen , Schmithausen, Patrick , Meyer, Imke , Friedrich, Mike , Dütting, Sebastian , Brede, Christian , Beilhack, Andreas , Schulze, Harald , Nieswandt, Bernhard and Heinze, Katrin G.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In mammals, megakaryocytes (MKs) in the bone marrow (BM) produce blood platelets, required for hemostasis and thrombosis. MKs originate from hematopoietic stem cells and are thought to migrate from an endosteal niche towards the vascular sinusoids during their maturation. Through imaging of MKs in the intact BM, here we show that MKs can be found w...
Alternative Titles
Full title
Thrombopoiesis is spatially regulated by the bone marrow vasculature
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TN_cdi_doaj_primary_oai_doaj_org_article_e135bb3de3894d00826f43b38e69be3f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e135bb3de3894d00826f43b38e69be3f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00201-7
