Topologically associating domain boundaries are required for normal genome function
Topologically associating domain boundaries are required for normal genome function
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Author / Creator
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States) , Rajderkar, Sudha , Barozzi, Iros , Zhu, Yiwen , Hu, Rong , Zhang, Yanxiao , Li, Bin , Alcaina Caro, Ana , Fukuda-Yuzawa, Yoko , Kelman, Guy , Akeza, Adyam , Blow, Matthew J. , Pham, Quan , Harrington, Anne N. , Godoy, Janeth , Meky, Eman M. , von Maydell, Kianna , Hunter, Riana D. , Akiyama, Jennifer A. , Novak, Catherine S. , Plajzer-Frick, Ingrid , Afzal, Veena , Tran, Stella , Lopez-Rios, Javier , Talkowski, Michael E. , Lloyd, K. C. Kent , Ren, Bing , Dickel, Diane E. , Visel, Axel and Pennacchio, Len A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Topologically associating domain (TAD) boundaries partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and cause disease phenotypes
1
–
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, but the overall extent to which this occurs remains unknown. Here we demonstrate that targeted delet...
Alternative Titles
Full title
Topologically associating domain boundaries are required for normal genome function
Authors, Artists and Contributors
Author / Creator
Rajderkar, Sudha
Barozzi, Iros
Zhu, Yiwen
Hu, Rong
Zhang, Yanxiao
Li, Bin
Alcaina Caro, Ana
Fukuda-Yuzawa, Yoko
Kelman, Guy
Akeza, Adyam
Blow, Matthew J.
Pham, Quan
Harrington, Anne N.
Godoy, Janeth
Meky, Eman M.
von Maydell, Kianna
Hunter, Riana D.
Akiyama, Jennifer A.
Novak, Catherine S.
Plajzer-Frick, Ingrid
Afzal, Veena
Tran, Stella
Lopez-Rios, Javier
Talkowski, Michael E.
Lloyd, K. C. Kent
Ren, Bing
Dickel, Diane E.
Visel, Axel
Pennacchio, Len A.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e14ddea1acbd44d0886ef92596b4bbe5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e14ddea1acbd44d0886ef92596b4bbe5
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-023-04819-w
