Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection
Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here, we show that matrix-embedded osteocytes stimulated with bacterial pathogen-associated molecular patterns (PAMPs) directly drive bone resorption through an MYD88-regulated signaling pathway. Mice lacking MYD88, primarily in osteocytes, protect against osteoly...
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Full title
Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection
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TN_cdi_doaj_primary_oai_doaj_org_article_e16f005c0ee94c278ec83641515e371c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e16f005c0ee94c278ec83641515e371c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34352-z
