Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchici...
Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine
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Switzerland: MDPI
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English
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Switzerland: MDPI
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Colchicine, a pseudoalkaloid isolated from Colchicum autumnale, has been identified as a potent anticancer agent because of its strong antimitotic activity. It was shown that colchicine modifications by regioselective demethylation affected its biological properties. For demethylated colchicine analogs, 10-demethylcolchicine (colchiceine, 1) and 1-...
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Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine
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TN_cdi_doaj_primary_oai_doaj_org_article_e170ffacf71241c5a4536d82690042b4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e170ffacf71241c5a4536d82690042b4
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules25051180
