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Cell division drives DNA methylation loss in late-replicating domains in primary human cells

Cell division drives DNA methylation loss in late-replicating domains in primary human cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e186c199ec3148bfa0903428332522e3

Cell division drives DNA methylation loss in late-replicating domains in primary human cells

About this item

Full title

Cell division drives DNA methylation loss in late-replicating domains in primary human cells

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2022-11, Vol.13 (1), p.6659-12, Article 6659

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

DNA methylation undergoes dramatic age-related changes, first described more than four decades ago. Loss of DNA methylation within partially methylated domains (PMDs), late-replicating regions of the genome attached to the nuclear lamina, advances with age in normal tissues, and is further exacerbated in cancer. We present here experimental evidenc...

Alternative Titles

Full title

Cell division drives DNA methylation loss in late-replicating domains in primary human cells

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_e186c199ec3148bfa0903428332522e3

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e186c199ec3148bfa0903428332522e3

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-022-34268-8

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