Cell division drives DNA methylation loss in late-replicating domains in primary human cells
Cell division drives DNA methylation loss in late-replicating domains in primary human cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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DNA methylation undergoes dramatic age-related changes, first described more than four decades ago. Loss of DNA methylation within partially methylated domains (PMDs), late-replicating regions of the genome attached to the nuclear lamina, advances with age in normal tissues, and is further exacerbated in cancer. We present here experimental evidenc...
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Cell division drives DNA methylation loss in late-replicating domains in primary human cells
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TN_cdi_doaj_primary_oai_doaj_org_article_e186c199ec3148bfa0903428332522e3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e186c199ec3148bfa0903428332522e3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34268-8