Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides
Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides
About this item
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Author / Creator
Cui, Yan-Ru , Wang, Shao-Jie , Chen, Jun , Li, Jie , Chen, Wenzhang , Wang, Shuyue , Meng, Bing , Zhu, Wei , Zhang, Zhuhong , Yang, Bei , Jiang, Biao , Yang, Guang , Ma, Peixiang and Liu, Jia
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
CRISPR-Cas9 has been developed as a therapeutic agent for various infectious and genetic diseases. In many clinically relevant applications, constitutively active CRISPR-Cas9 is delivered into human cells without a temporal control system. Excessive and prolonged expression of CRISPR-Cas9 can lead to elevated off-target cleavage. The need for modul...
Alternative Titles
Full title
Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e1fec939b0024c61a074692d3e01e9b2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e1fec939b0024c61a074692d3e01e9b2
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-020-01956-x
