First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4...
First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers
About this item
Full title
Author / Creator
Hong, David S , Parikh, Aparna , Shapiro, Geoffrey I , Varga, Andrea , Naing, Aung , Meric-Bernstam, Funda , Ataman, Özlem , Reyderman, Larisa , Binder, Terri A , Ren, Min , Liu, Mingjie , Dayal, Satish , Siu, Amy Y , Sachdev, Pallavi , Xu, Lucy , Bhagawati-Prasad, Vijay , Tchakov, Ilian , Ooi, Chean Eng , Bao, Xingfeng and Marabelle, Aurelien
Publisher
London: BMJ Publishing Group Ltd
Journal title
Language
English
Formats
Publication information
Publisher
London: BMJ Publishing Group Ltd
Subjects
More information
Scope and Contents
Contents
BackgroundE7046 is a highly selective, small-molecule antagonist of the E-type prostanoid receptor 4 (EP4) for prostaglandin E2, an immunosuppressive mediator of the tumor immune microenvironment. This first-in-human phase 1 study assessed the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose (MTD) and recommended pha...
Alternative Titles
Full title
First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers
Authors, Artists and Contributors
Author / Creator
Parikh, Aparna
Shapiro, Geoffrey I
Varga, Andrea
Naing, Aung
Meric-Bernstam, Funda
Ataman, Özlem
Reyderman, Larisa
Binder, Terri A
Ren, Min
Liu, Mingjie
Dayal, Satish
Siu, Amy Y
Sachdev, Pallavi
Xu, Lucy
Bhagawati-Prasad, Vijay
Tchakov, Ilian
Ooi, Chean Eng
Bao, Xingfeng
Marabelle, Aurelien
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e224332c09c046d89e9e666fa3f6b4e3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e224332c09c046d89e9e666fa3f6b4e3
Other Identifiers
E-ISSN
2051-1426
DOI
10.1136/jitc-2019-000222
