Structure-Based Identification of SARS-CoV-2 nsp10-16 Methyltransferase Inhibitors Using Molecular D...
Structure-Based Identification of SARS-CoV-2 nsp10-16 Methyltransferase Inhibitors Using Molecular Dynamics Insights
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Publisher
Switzerland: MDPI
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Language
English
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Publisher
Switzerland: MDPI
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SARS-CoV-2 evades immune detection via nsp10-16 methyltransferase-mediated 2'-O-methylation of viral mRNA, making it a key antiviral target. Our study employed structure-based drug discovery-including virtual screening, molecular docking, and molecular dynamics (MD) simulations-to identify potent inhibitors of nsp10-16. We identified seven promisin...
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Full title
Structure-Based Identification of SARS-CoV-2 nsp10-16 Methyltransferase Inhibitors Using Molecular Dynamics Insights
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TN_cdi_doaj_primary_oai_doaj_org_article_e23acd230bf04144a44429c808d4a72f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e23acd230bf04144a44429c808d4a72f
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ISSN
1467-3045,1467-3037
E-ISSN
1467-3045
DOI
10.3390/cimb47030198
