Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer...
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Mammalian 2-Cys peroxiredoxin (Prx) enzymes are overexpressed in most cancer tissues, but their specific signaling role in cancer progression is poorly understood. Here we demonstrate that Prx type II (PrxII) plays a tumor-promoting role in colorectal cancer by interacting with a poly(ADP-ribose) polymerase (PARP) tankyrase.
PrxII
deletion in...
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Full title
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
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TN_cdi_doaj_primary_oai_doaj_org_article_e27578deda874e92af1b15fb7b61a1bd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e27578deda874e92af1b15fb7b61a1bd
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00054-0
