The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosoma...
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
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Author / Creator
Jones-Tabah, Jace , He, Kathy , Karpilovsky, Nathan , Senkevich, Konstantin , Deyab, Ghislaine , Pietrantonio, Isabella , Goiran, Thomas , Cousineau, Yuting , Nikanorova, Daria , Goldsmith, Taylor , del Cid Pellitero, Esther , Chen, Carol X.-Q. , Luo, Wen , You, Zhipeng , Abdian, Narges , Ahmad, Jamil , Ruskey, Jennifer A. , Asayesh, Farnaz , Spiegelman, Dan , Fahn, Stanley , Waters, Cheryl , Monchi, Oury , Dauvilliers, Yves , Dupré, Nicolas , Miliukhina, Irina , Timofeeva, Alla , Emelyanov, Anton , Pchelina, Sofya , Greenbaum, Lior , Hassin-Baer, Sharon , Alcalay, Roy N. , Milnerwood, Austen , Durcan, Thomas M. , Gan-Or, Ziv and Fon, Edward A.
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B (catB) are associated with increased risk of Parkinson's disease (PD). However, neither the specific CTSB variants driving these associations nor the functional pathways that link catB to PD pathogenesis have been characterized. CatB activity contributes to lysosomal protein deg...
Alternative Titles
Full title
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Authors, Artists and Contributors
Author / Creator
He, Kathy
Karpilovsky, Nathan
Senkevich, Konstantin
Deyab, Ghislaine
Pietrantonio, Isabella
Goiran, Thomas
Cousineau, Yuting
Nikanorova, Daria
Goldsmith, Taylor
del Cid Pellitero, Esther
Chen, Carol X.-Q.
Luo, Wen
You, Zhipeng
Abdian, Narges
Ahmad, Jamil
Ruskey, Jennifer A.
Asayesh, Farnaz
Spiegelman, Dan
Fahn, Stanley
Waters, Cheryl
Monchi, Oury
Dauvilliers, Yves
Dupré, Nicolas
Miliukhina, Irina
Timofeeva, Alla
Emelyanov, Anton
Pchelina, Sofya
Greenbaum, Lior
Hassin-Baer, Sharon
Alcalay, Roy N.
Milnerwood, Austen
Durcan, Thomas M.
Gan-Or, Ziv
Fon, Edward A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e2786b44f0ab42b995b54fb1787459cd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e2786b44f0ab42b995b54fb1787459cd
Other Identifiers
ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-024-00779-9
