Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell respons...
Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
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Author / Creator
Eskandari-Sedighi, Ghazaleh , Crichton, Madeline , Zia, Sameera , Gomez-Cardona, Erik , Cortez, Leonardo M , Patel, Zain H , Takahashi-Yamashiro, Kei , St Laurent, Chris D , Sidhu, Gaurav , Sarkar, Susmita , Aghanya, Vivian , Sim, Valerie L , Tan, Qiumin , Julien, Olivier , Plemel, Jason R and Macauley, Matthew S
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Microglia play diverse pathophysiological roles in Alzheimer's disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility through a single nucleotide polymorphism that modulates mRNA splicing, skewing protein expression from a long p...
Alternative Titles
Full title
Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e2bd71e630ca42e2903e16f780fc40b0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e2bd71e630ca42e2903e16f780fc40b0
Other Identifiers
ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-024-00734-8
