Mechanical stress determines the configuration of TGFβ activation in articular cartilage
Mechanical stress determines the configuration of TGFβ activation in articular cartilage
About this item
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Author / Creator
Zhen, Gehua , Guo, Qiaoyue , Li, Yusheng , Wu, Chuanlong , Zhu, Shouan , Wang, Ruomei , Guo, X. Edward , Kim, Byoung Choul , Huang, Jessie , Hu, Yizhong , Dan, Yang , Wan, Mei , Ha, Taekjip , An, Steven and Cao, Xu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional relationship between subchondral bone (SB) and articular cartilage (AC) is unclear. Here, we found that the changes of SB architecture altered the distribution of mechanical stress on AC. Important...
Alternative Titles
Full title
Mechanical stress determines the configuration of TGFβ activation in articular cartilage
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e2cbba79acc140fcb2a2e1bea0be1268
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e2cbba79acc140fcb2a2e1bea0be1268
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21948-0
