STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles
STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1
hi
, but compared to their CD57− PD-1
hi
counterparts, express little IL-21 or IL-10 among others. Instead, CD57 expression on TFH cells marks cytotoxicity transcrip...
Alternative Titles
Full title
STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles
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TN_cdi_doaj_primary_oai_doaj_org_article_e2eb94b50da340409764c3fb20783667
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e2eb94b50da340409764c3fb20783667
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-21389-8
