Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in...
Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
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Author / Creator
Yu, Siyuan , Yang, Han , Li, Tingdong , Pan, Haifeng , Ren, Shuling , Luo, Guoxing , Jiang, Jinlu , Yu, Linqi , Chen, Binbing , Zhang, Yali , Wang, Shaojuan , Tian, Rui , Zhang, Tianying , Zhang, Shiyin , Chen, Yixin , Yuan, Quan , Ge, Shengxiang , Zhang, Jun and Xia, Ningshao
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Protein delivery with cell-penetrating peptide is opening up the possibility of using targets inside cells for therapeutic or biological applications; however, cell-penetrating peptide-mediated protein delivery commonly suffers from ineffective endosomal escape and low tolerance in serum, thereby limiting in vivo efficacy. Here, we present an intra...
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Full title
Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_e30762d64de74ddb83def6a74c94fb19
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e30762d64de74ddb83def6a74c94fb19
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25448-z
