p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
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Author / Creator
Quiñones, Mar , Al-Massadi, Omar , Folgueira, Cintia , Bremser, Stephan , Gallego, Rosalía , Torres-Leal, Leonardo , Haddad-Tóvolli, Roberta , García-Caceres, Cristina , Hernandez-Bautista, Rene , Lam, Brian Y. H. , Beiroa, Daniel , Sanchez-Rebordelo, Estrella , Senra, Ana , Malagon, Jose A. , Valerio, Patricia , Fondevila, Marcos F. , Fernø, Johan , Malagon, Maria M. , Contreras, Raian , Pfluger, Paul , Brüning, Jens C. , Yeo, Giles , Tschöp, Matthias , Diéguez, Carlos , López, Miguel , Claret, Marc , Kloppenburg, Peter , Sabio, Guadalupe and Nogueiras, Ruben
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide (AgRP), but not proopiomelanocortin (POMC) or steroidogenic factor-1 (SF1) neurons, are more prone to develop diet-induced ob...
Alternative Titles
Full title
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
Authors, Artists and Contributors
Author / Creator
Al-Massadi, Omar
Folgueira, Cintia
Bremser, Stephan
Gallego, Rosalía
Torres-Leal, Leonardo
Haddad-Tóvolli, Roberta
García-Caceres, Cristina
Hernandez-Bautista, Rene
Lam, Brian Y. H.
Beiroa, Daniel
Sanchez-Rebordelo, Estrella
Senra, Ana
Malagon, Jose A.
Valerio, Patricia
Fondevila, Marcos F.
Fernø, Johan
Malagon, Maria M.
Contreras, Raian
Pfluger, Paul
Brüning, Jens C.
Yeo, Giles
Tschöp, Matthias
Diéguez, Carlos
López, Miguel
Claret, Marc
Kloppenburg, Peter
Sabio, Guadalupe
Nogueiras, Ruben
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e3abcb467c8540338b4c0581b476791c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e3abcb467c8540338b4c0581b476791c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05711-6
