Design of MMP-1 inhibitors via SAR transfer and experimental validation
Design of MMP-1 inhibitors via SAR transfer and experimental validation
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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New matrix metalloproteinase 1 (MMP-1) inhibitors were predicted using the structure–activity relationship (SAR) transfer method based on a series of analogues of kinesin-like protein 11 (KIF11) inhibitors. Compounds
5
–
7
predicted to be highly potent against MMP-1 were synthesized and tested for MMP-1 inhibitory activity. Among these,...
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Design of MMP-1 inhibitors via SAR transfer and experimental validation
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TN_cdi_doaj_primary_oai_doaj_org_article_e3d1a7b258214a2e91f62651ec92278c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e3d1a7b258214a2e91f62651ec92278c
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-25079-4
