Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overlo...
Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The relationship between LRRK2 mutations and susceptibility to synuclein pathology in Parkinson’s disease (PD) is still unclear. We here investigate whether the mice carrying the D1994S kinase-dead (KD) mutation of LRRK2 show enhanced susceptibility to synucleinopathy. Twelve-month-old LRRK2 KD and WT mice were injected with AAV2/9 carrying human A...
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Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2
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TN_cdi_doaj_primary_oai_doaj_org_article_e3e3f86ddaa34809ab7a7ba32858a01a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e3e3f86ddaa34809ab7a7ba32858a01a
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2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-025-94165-0
