Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
About this item
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Author / Creator
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States) , Thavalingam, Annoj , Cheng, Zhi , Garcia, Bianca , Huang, Xue , Shah, Megha , Sun, Wei , Wang, Min , Harrington, Lucas , Hwang, Sungwon , Hidalgo-Reyes, Yurima , Sontheimer, Erik J. , Doudna, Jennifer , Davidson, Alan R. , Moraes, Trevor F. , Wang, Yanli and Maxwell, Karen L.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
CRISPR-Cas adaptive immune systems function to protect bacteria from invasion by foreign genetic elements. The CRISPR-Cas9 system has been widely adopted as a powerful genome-editing tool, and phage-encoded inhibitors, known as anti-CRISPRs, offer a means of regulating its activity. Here, we report the crystal structures of anti-CRISPR protein AcrI...
Alternative Titles
Full title
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
Authors, Artists and Contributors
Author / Creator
Thavalingam, Annoj
Cheng, Zhi
Garcia, Bianca
Huang, Xue
Shah, Megha
Sun, Wei
Wang, Min
Harrington, Lucas
Hwang, Sungwon
Hidalgo-Reyes, Yurima
Sontheimer, Erik J.
Doudna, Jennifer
Davidson, Alan R.
Moraes, Trevor F.
Wang, Yanli
Maxwell, Karen L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e4066aeabab14fe3b824f6c38d4f8d8d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4066aeabab14fe3b824f6c38d4f8d8d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10577-3
