SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differe...
SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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SHANK2
mutations have been identified in individuals with neurodevelopmental disorders, including intellectual disability and autism spectrum disorders (ASD). Using CRISPR/Cas9 genome editing, we obtained SH-SY5Y cell lines with frameshift mutations on one or both
SHANK2
alleles. We investigated the effects of the different
SHANK2
mu...
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Full title
SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells
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TN_cdi_doaj_primary_oai_doaj_org_article_e4089156251d45adb3fc38da76c6052a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4089156251d45adb3fc38da76c6052a
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-81241-4
