Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η
Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
A wide range of endogenous and exogenous alkylating agents attack DNA to generate various alkylation adducts. N7-methyl-2-deoxyguanosine (Fm7dG) is the most abundant alkylative DNA lesion. If not repaired, Fm7dG can undergo spontaneous depurination, imidazole ring-opening, or bypass by translesion synthesis DNA polymerases. Human DNA polymerase η (...
Alternative Titles
Full title
Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η
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TN_cdi_doaj_primary_oai_doaj_org_article_e43b846c0e6141ec928359ab3686decf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e43b846c0e6141ec928359ab3686decf
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules24213928
