Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lu...
Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients
About this item
Full title
Author / Creator
Chabon, Jacob J. , Simmons, Andrew D. , Lovejoy, Alexander F. , Esfahani, Mohammad S. , Newman, Aaron M. , Haringsma, Henry J. , Kurtz, David M. , Stehr, Henning , Scherer, Florian , Karlovich, Chris A. , Harding, Thomas C. , Durkin, Kathleen A. , Otterson, Gregory A. , Purcell, W. Thomas , Camidge, D. Ross , Goldman, Jonathan W. , Sequist, Lecia V. , Piotrowska, Zofia , Wakelee, Heather A. , Neal, Joel W. , Alizadeh, Ash A. and Diehn, Maximilian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Circulating tumour DNA (ctDNA) analysis facilitates studies of tumour heterogeneity. Here we employ CAPP-Seq ctDNA analysis to study resistance mechanisms in 43 non-small cell lung cancer (NSCLC) patients treated with the third-generation epidermal growth factor receptor (EGFR) inhibitor rociletinib. We observe multiple resistance mechanisms in 46%...
Alternative Titles
Full title
Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients
Authors, Artists and Contributors
Author / Creator
Simmons, Andrew D.
Lovejoy, Alexander F.
Esfahani, Mohammad S.
Newman, Aaron M.
Haringsma, Henry J.
Kurtz, David M.
Stehr, Henning
Scherer, Florian
Karlovich, Chris A.
Harding, Thomas C.
Durkin, Kathleen A.
Otterson, Gregory A.
Purcell, W. Thomas
Camidge, D. Ross
Goldman, Jonathan W.
Sequist, Lecia V.
Piotrowska, Zofia
Wakelee, Heather A.
Neal, Joel W.
Alizadeh, Ash A.
Diehn, Maximilian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e467721976a7414699480c405cfa9845
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e467721976a7414699480c405cfa9845
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11815
