PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint bl...
PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
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Author / Creator
Peng, Qi , Qiu, Xiangyan , Zhang, Zihan , Zhang, Silin , Zhang, Yuanyuan , Liang, Yong , Guo, Jingya , Peng, Hua , Chen, Mingyi , Fu, Yang-Xin and Tang, Haidong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Immune checkpoint blockade therapies have shown clinical promise in a variety of cancers, but how tumor-infiltrating T cells are activated remains unclear. In this study, we explore the functions of PD-L1 on dendritic cells (DCs), which highly express PD-L1. We observe that PD-L1 on DC plays a critical role in limiting T cell responses. Type 1 conv...
Alternative Titles
Full title
PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e4ab035ca87340ce8581f2ec446042ea
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4ab035ca87340ce8581f2ec446042ea
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18570-x
