PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo traffi...
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer
About this item
Full title
Author / Creator
Salvi, Amrita , Young, Alexandria N. , Huntsman, Andrew C. , Pergande, Melissa R. , Korkmaz, Melissa A. , Rathnayake, Rathnayake A. , Mize, Brittney K. , Kinghorn, A. Douglas , Zhang, Xiaoli , Ratia, Kiira , Schirle, Markus , Thomas, Jason R. , Brittain, Scott M. , Shelton, Claude , Aldrich, Leslie N. , Cologna, Stephanie M. , Fuchs, James R. and Burdette, Joanna E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the
Phyllanthus
genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer (HGSOC) cells. Mechanistically, PHY34 induced apoptosis in ovarian cancer cells by late-stage autophag...
Alternative Titles
Full title
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer
Authors, Artists and Contributors
Author / Creator
Young, Alexandria N.
Huntsman, Andrew C.
Pergande, Melissa R.
Korkmaz, Melissa A.
Rathnayake, Rathnayake A.
Mize, Brittney K.
Kinghorn, A. Douglas
Zhang, Xiaoli
Ratia, Kiira
Schirle, Markus
Thomas, Jason R.
Brittain, Scott M.
Shelton, Claude
Aldrich, Leslie N.
Cologna, Stephanie M.
Fuchs, James R.
Burdette, Joanna E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e4c4de122bed46cdace434fd84397a5c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4c4de122bed46cdace434fd84397a5c
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-04495-w
