An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
About this item
Full title
Author / Creator
El-Husseini, Zaid W. , Khalenkow, Dmitry , Lan, Andy , van der Molen, Thys , Brightling, Chris , Papi, Alberto , Rabe, Klaus F. , Siddiqui, Salman , Singh, Dave , Kraft, Monica , Beghe, Bianca , van den Berge, Maarten , van Gosliga, Djoke , Nawijn, Martijn C. , Rose-John, Stefan , Koppelman, Gerard H. and Gosens, Reinoud
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signaling to severe asthma. IL-6 cooperates with soluble-IL-6Rα to activate cell signaling in airway epithelium.
We sought to study the role of...
Alternative Titles
Full title
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e4d93162eadc447d86daca4b0d26e0df
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4d93162eadc447d86daca4b0d26e0df
Other Identifiers
ISSN
1465-993X,1465-9921
E-ISSN
1465-993X,1465-9921
DOI
10.1186/s12931-023-02617-w
