GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors
GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Mutant KRas is a significant driver of human oncogenesis and confers resistance to therapy, underscoring the need to develop approaches that disable mutant KRas-driven tumors. Because targeting KRas directly has proven difficult, identifying vulnerabilities specific for mutant KRas tumors is an important alternative approach. Here we show that glyc...
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GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors
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TN_cdi_doaj_primary_oai_doaj_org_article_e4dd4e549d124d48b1ca42f85db738ff
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4dd4e549d124d48b1ca42f85db738ff
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07644-6
