Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in l...
Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer
About this item
Full title
Author / Creator
Macaya, Irati , Roman, Marta , Welch, Connor , Entrialgo-Cadierno, Rodrigo , Salmon, Marina , Santos, Alba , Feliu, Iker , Kovalski, Joanna , Lopez, Ines , Rodriguez-Remirez, Maria , Palomino-Echeverria, Sara , Lonfgren, Shane M. , Ferrero, Macarena , Calabuig, Silvia , Ludwig, Iziar A. , Lara-Astiaso, David , Jantus-Lewintre, Eloisa , Guruceaga, Elizabeth , Narayanan, Shruthi , Ponz-Sarvise, Mariano , Pineda-Lucena, Antonio , Lecanda, Fernando , Ruggero, Davide , Khatri, Purvesh , Santamaria, Enrique , Fernandez-Irigoyen, Joaquin , Ferrer, Irene , Paz-Ares, Luis , Drosten, Matthias , Barbacid, Mariano , Gil-Bazo, Ignacio and Vicent, Silve
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the context of KRAS-mutated lung cancers focuses fundamentally on targeting KRAS proximal activators or effectors. However, the antitu...
Alternative Titles
Full title
Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer
Authors, Artists and Contributors
Author / Creator
Roman, Marta
Welch, Connor
Entrialgo-Cadierno, Rodrigo
Salmon, Marina
Santos, Alba
Feliu, Iker
Kovalski, Joanna
Lopez, Ines
Rodriguez-Remirez, Maria
Palomino-Echeverria, Sara
Lonfgren, Shane M.
Ferrero, Macarena
Calabuig, Silvia
Ludwig, Iziar A.
Lara-Astiaso, David
Jantus-Lewintre, Eloisa
Guruceaga, Elizabeth
Narayanan, Shruthi
Ponz-Sarvise, Mariano
Pineda-Lucena, Antonio
Lecanda, Fernando
Ruggero, Davide
Khatri, Purvesh
Santamaria, Enrique
Fernandez-Irigoyen, Joaquin
Ferrer, Irene
Paz-Ares, Luis
Drosten, Matthias
Barbacid, Mariano
Gil-Bazo, Ignacio
Vicent, Silve
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e4df0207a07b4df791d9fb4bec0b4c62
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4df0207a07b4df791d9fb4bec0b4c62
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41828-z
