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In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines

In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4e7d7d3c4fe4e64adcffc572b4ed1ec

In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines

About this item

Full title

In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2023-08, Vol.13 (1), p.12675-12675, Article 12675

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Intrinsic or added immune activating molecules are key for most vaccines to provide desired immunity profiles but may increase systemic reactogenicity. Regulatory agencies require rabbit pyrogen testing (RPT) for demonstration of vaccine reactogenicity. Recently, the monocyte activation test (MAT) gained popularity as in vitro alternative, yet this...

Alternative Titles

Full title

In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_e4e7d7d3c4fe4e64adcffc572b4ed1ec

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4e7d7d3c4fe4e64adcffc572b4ed1ec

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-023-39908-7

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