The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand brea...
The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair
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Author / Creator
Huang, Tao , Yuan, Shenli , Gao, Lei , Li, Mengjing , Yu, Xiaochen , Zhan, Jianhong , Yin, Yingying , Liu, Chao , Zhang, Chuanxin , Lu, Gang , Li, Wei , Liu, Jiang , Chen, Zi-Jiang and Liu, Hongbin
Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
The histone modification writer Prdm9 has been shown to deposit H3K4me3 and H3K36me3 at future double-strand break (DSB) sites during the very early stages of meiosis, but the reader of these marks remains unclear. Here, we demonstrate that Zcwpw1 is an H3K4me3 reader that is required for DSB repair and synapsis in mouse testes. We generated H3K4me...
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Full title
The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair
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TN_cdi_doaj_primary_oai_doaj_org_article_e5347438168f41b892eb82ce181ef10c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e5347438168f41b892eb82ce181ef10c
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.53459
