Pharmacokinetic Interaction Between Olaparib and Regorafenib in an Animal Model
Pharmacokinetic Interaction Between Olaparib and Regorafenib in an Animal Model
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Background: Olaparib (OLA) and regorafenib (REG) are metabolized by the CYP3A4 isoenzyme of cytochrome P450. Both drugs are also substrates and inhibitors of the membrane transporters P-glycoprotein and BCRP. Therefore, the potential concomitant use of OLA and REG may result in clinically relevant drug–drug interactions. Knowledge of the influence...
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Full title
Pharmacokinetic Interaction Between Olaparib and Regorafenib in an Animal Model
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TN_cdi_doaj_primary_oai_doaj_org_article_e5379e4c50f1474e847fef85dd75b8f8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e5379e4c50f1474e847fef85dd75b8f8
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ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics16121575
